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Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

Epigenetics and cardiovascular disease.

José M Ordovás¹, Caren E Smith

¹Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA. jose.ordovas@tufts.edu

Nature Reviews. Cardiology

|July 7, 2010

Summary

This summary is machine-generated.

Epigenomics, the study of gene expression changes, offers new insights into cardiovascular disease (CVD) development. Understanding epigenetic mechanisms linked to CVD risk factors may lead to earlier prevention and novel therapies.

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Area of Science:

Genetics and genomics
Molecular biology
Cardiovascular research

Background:

Cardiovascular disease (CVD) remains a leading global cause of mortality.
Current understanding of CVD risk factors, including genetic and environmental influences, is incomplete.
Existing knowledge explains only a small portion of CVD risk variability, hindering effective prevention and treatment.

Purpose of the Study:

To explore the role of epigenomics in understanding the multifactorial nature of cardiovascular disease.
To identify how environmental factors interact with genetic predispositions in CVD development.
To highlight the potential of 'omics' technologies in advancing CVD prevention and therapy.

Main Methods:

Review of current literature on epigenetics and cardiovascular disease.
Focus on epigenetic mechanisms: DNA methylation, histone modification, and microRNA alterations.
Examination of associations between CVD risk factors (nutrition, smoking, pollution, stress, circadian rhythm) and epigenetic modifications.

Main Results:

Epigenetic mechanisms provide a crucial link between environmental exposures and CVD risk.
Environmental factors like nutrition, smoking, and pollution can alter epigenetic marks.
These alterations influence cellular responses and contribute to CVD development.

Conclusions:

Epigenomics is a promising field for addressing knowledge gaps in CVD etiology.
Understanding epigenetic modifications offers potential for earlier CVD prevention strategies.
Targeting epigenetic mechanisms may lead to the development of novel and effective CVD therapies.