Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Late variation in ventricular function after myocardial infarction.

V H Humbert1, H Jabi, A J Burger

  • 1Department of Medicine, Marshall University School of Medicine, Huntington, WV.

Chest
|July 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nesiritide: past, present, and future.

Minerva cardioangiologica·2005
Same author

Diabetes and the occurrence of ventricular arrhythmic events in patients with severe left ventricular dysfunction.

Diabetologia·2002
Same author

Role of endothelin in modulation of heart rate variability in patients with decompensated heart failure.

Pacing and clinical electrophysiology : PACE·2002
Same author

BNP in decompensated heart failure: diagnostic, prognostic and therapeutic potential.

Current opinion in investigational drugs (London, England : 2000)·2002
Same author

Blunted sympathetic response in diabetic patients with decompensated congestive heart failure.

International journal of cardiology·2001
Same author

Diabetic autonomic neuropathy: the clinical interpretation of improved technology.

Diabetes technology & therapeutics·2001

Predicting late ventricular function after myocardial infarction (MI) is crucial. Early left ventricular ejection fraction (LVEF) and Q-wave status significantly influence long-term recovery, with a notable "regression to the mean" effect observed.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Clinical Research

Background:

  • Assessing long-term ventricular function post-myocardial infarction (MI) is vital.
  • Identifying predictors beyond early artery reperfusion is necessary for comprehensive patient management.
  • Understanding late functional changes aids in developing targeted therapeutic strategies.

Purpose of the Study:

  • To investigate non-reperfusion variables that predict late changes in left ventricular ejection fraction (LVEF) after MI.
  • To analyze the relationship between early echocardiographic findings and long-term ventricular function.
  • To evaluate the influence of specific infarction characteristics on functional recovery.

Main Methods:

  • Retrospective review of paired echocardiograms (early and late) from 54 MI survivors.

Related Experiment Videos

  • Calculation of LVEF using digitized biapical views and a graphics tablet.
  • Correlation analysis between LVEF changes (>=0.10) and 23 clinical variables using stepwise regression.

    • Main Results:

    • Q-wave infarction and low early LVEF independently predicted late functional improvement.
    • High early LVEF and interval infarction predicted late functional decline.
    • A significant "regression to the mean" effect was observed: high early LVEF decreased, and low early LVEF increased over time (r = -0.44, p < 0.001).

    Conclusions:

    • Early LVEF and infarction type are key predictors of late ventricular function changes post-MI.
    • The "regression to the mean" phenomenon must be considered in acute MI intervention trials.
    • Q-wave infarction does not preclude the possibility of late functional improvement.