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Numerosity impairment in corticobasal syndrome
Shira Koss1, Robin Clark, Luisa Vesely
1Department of Neurology, University of Pennsylvania, PA, USA.
Neuropsychology
|July 8, 2010
Summary
Corticobasal syndrome (CBS) patients show impaired numerosity representation, performing significantly worse and slower than controls. This deficit in understanding number sense is linked to parietal lobe atrophy.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Neurology
Background:
- Corticobasal syndrome (CBS) is a progressive neurodegenerative disorder primarily affecting the parietal lobe.
- Understanding numerical cognition is crucial for assessing cognitive function in neurodegenerative diseases.
Purpose of the Study:
- To investigate the representation of numerosity in individuals with corticobasal syndrome (CBS).
- To determine if CBS impacts the ability to judge numerical magnitudes and differentiate between quantities.
Main Methods:
- Participants judged if a target numerosity fell between two bounding numerosities, using Arabic numerals or dot arrays.
- Manipulations included format, gap size, magnitude, and presentation order of numerosities.
- Voxel-based morphometry correlated performance with cortical atrophy in a subset of patients.
Main Results:
- CBS patients exhibited significant impairments in numerosity judgment (65.7%) compared to healthy controls (96.6%).
- CBS patients were substantially slower than controls, with deficits independent of numerical format, gap size, or magnitude.
- Voxel-based morphometry revealed significant parietal and frontal cortical atrophy, including the intraparietal sulcus, in CBS patients.
Conclusions:
- The findings indicate a degraded representation of numerosity in corticobasal syndrome.
- Parietal lobe atrophy, particularly in regions like the intraparietal sulcus, is associated with numerical processing deficits in CBS.
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