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Updated: Jun 11, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
Adjustments of conflict monitoring in Parkinson's disease
Camille A Bonnin1, Jean-Luc Houeto, Roger Gil
1Research Center on Cognition and Learning, University of Poitiers, France.
Objective:
In Stroop-like tasks, the detection of conflict triggers adjustments of cognitive control to reduce conflict in subsequent trials. The present study tested the hypothesis of an impaired modulation of conflict monitoring in Parkinson's disease (PD).
Method:
18 PD patients and 18 healthy control (HC) participants performed a Stroop-like task in 2 conditions differing in terms of incongruent/congruent stimuli ratio.
Results:
HC participants demonstrated a sustained modulation of interference effect, the interference effect being decreased when the proportion of incongruent stimuli was high. A trial-by-trial analysis also showed that in the HC group, processing an incongruent stimulus reduced interference in the subsequent trial. Unlike controls, PD patients did not demonstrate any transient or sustained reduction of the interference effect.
Conclusion:
Within the framework of recent models, these results can be interpreted as an impairment of a proactive mode of cognitive control in patients with PD.
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