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Related Concept Videos

Structure of Cardiac Muscles01:13

Structure of Cardiac Muscles

Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
Specialized Characteristics of Cardiac Muscles01:27

Specialized Characteristics of Cardiac Muscles

The primary role of cardiac muscles is to propel blood throughout the cardiovascular system. The cardiac muscle cells, or cardiomyocytes, exhibit specialized characteristics that allow them to perform this function.
Cardiac muscle cells are smaller than skeletal muscles, averaging 10–20 mm in diameter and 50–100 mm in length. However, they have large energy demands for continuous contraction and relaxation. This energy is almost exclusively derived from aerobic metabolism of energy reserves in...
Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...

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Related Experiment Video

Updated: Jun 11, 2026

Isolating Primary Melanocyte-like Cells from the Mouse Heart
07:38

Isolating Primary Melanocyte-like Cells from the Mouse Heart

Published on: September 29, 2014

Myocardial telocytes: a specific new cellular entity.

Sawa Kostin1

  • 1Max-Planck Institute for Heart and Lung Research (W.C. Kerckhoff Institute), Bad Nauheim, Germany. sawa.kostin@mpi-bn.mpg.de

Journal of Cellular and Molecular Medicine
|July 8, 2010
PubMed
Summary
This summary is machine-generated.

Interstitial Cajal-like cells (ICLC), now termed telocytes, are a distinct myocardial cell type. Evidence supports their roles in cardiac signaling, repair, and stem cell regulation.

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Related Experiment Videos

Last Updated: Jun 11, 2026

Isolating Primary Melanocyte-like Cells from the Mouse Heart
07:38

Isolating Primary Melanocyte-like Cells from the Mouse Heart

Published on: September 29, 2014

Isolation of Murine Intestinal Mesenchyme Resulting in a High Yield of Telocytes
06:35

Isolation of Murine Intestinal Mesenchyme Resulting in a High Yield of Telocytes

Published on: March 24, 2023

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
08:15

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Published on: October 8, 2016

Area of Science:

  • Cardiology
  • Cell Biology
  • Histology

Background:

  • Interstitial Cajal-like cells (ICLC) were first described in 2005.
  • Research on ICLC morphology, phenotype, and distribution has increased across species.
  • Telocytes and telopodes are proposed new terms for ICLC and their prolongations.

Purpose of the Study:

  • To present critical data on myocardial telocytes.
  • To provide evidence for telocytes as a distinct myocardial interstitial cell type.
  • To discuss the potential functions of myocardial telocytes.

Main Methods:

  • Identification based on ultrastructural criteria.
  • Complementary identification using methylene blue vital staining.
  • Immunoreactivity against CD117/c-kit and vimentin.

Main Results:

  • Telocytes are a distinct cellular entity within the myocardial interstitium.
  • Compelling evidence supports the unique nature of these cells.
  • Multiple identification methods confirm their presence.

Conclusions:

  • Myocardial telocytes represent a novel cell type.
  • Potential functions include intercellular signaling.
  • Roles in cardiac repair, remodeling, and stem cell nursing are proposed.