Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Seizure interactions between the inferior collicular cortex and the deep prepiriform cortex.

T J McCown1, G R Breese

  • 1Department of Psychiatry, University of North Carolina, Chapel Hill 27599-7520.

Epilepsy Research
|January 1, 1991
PubMed
Summary

This study in rats shows that brain activity during seizures doesn't always match observable behaviors. However, the deep prepiriform cortex can control seizure spread from the inferior colliculus to the forebrain.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropism.

Gene therapy·2016
Same author

Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primates.

Gene therapy·2013
Same author

The influence of epileptic neuropathology and prior peripheral immunity on CNS transduction by rAAV2 and rAAV5.

Gene therapy·2011
Same author

Delivering multiple gene products in the brain from a single adeno-associated virus vector.

Gene therapy·2009
Same author

Cerebellar cGMP varies with motor function and respiratory gas exchange.

Neuroscience letters·2009
Same author

Adeno-associated virus-mediated expression and constitutive secretion of NPY or NPY13-36 suppresses seizure activity in vivo.

Gene therapy·2007

Area of Science:

  • Neuroscience
  • Epilepsy Research

Background:

  • Seizure activity involves complex brain network interactions.
  • Understanding the relationship between electrographic and behavioral seizure manifestations is crucial for epilepsy research.

Purpose of the Study:

  • To investigate the relationship between electrographic seizure activity and behavioral seizure manifestations in rats.
  • To explore the role of the deep prepiriform cortex in modulating seizure generalization.

Main Methods:

  • Electrographic seizure activity was recorded from the inferior collicular cortex and deep prepiriform cortex in rats.
  • Bicuculline was administered to induce seizures.
  • Procaine microinjections were used to assess functional interactions between brain regions.

Related Experiment Videos

Main Results:

  • Bicuculline induced electrographic seizure activity and behavioral seizures, with specific correlations between brain regions and behaviors.
  • Dissociation between electrographic and behavioral seizure activity was observed.
  • Microinjections of procaine into the deep prepiriform cortex prevented seizure generalization from the inferior colliculus.

Conclusions:

  • The deep prepiriform cortex, a forebrain site linked to limbic seizures, plays a role in modulating seizure generalization.
  • There can be a dissociation between electrographic seizure patterns and observable seizure behaviors.
  • Findings highlight the complex interplay between different brain regions in seizure propagation.