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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Stroke in women
1Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, United States. sylvia.smoller@einstein.yu.edu
Insights
Stroke is a significant health concern for women, ranking as the third leading cause of death. Effective management of risk factors like high blood pressure and diabetes can reduce stroke-related mortality and disability.
Area of Science:
- Neurology
- Cardiovascular Medicine
- Public Health
Background:
- Stroke is the third leading cause of death in women.
- Risk factors for stroke are numerous and varied, impacting women differently.
- Understanding these factors is crucial for effective prevention strategies.
Observation:
- Key risk factors include hypertension, atrial fibrillation, diabetes, and smoking.
- Hormone therapy in postmenopausal women increases ischemic stroke risk.
- Inflammation biomarkers, lipids, inactivity, and diet also contribute to stroke risk.
Findings:
- Stroke risk escalates significantly with the presence of multiple risk factors.
- Hypertension control remains suboptimal in older women, despite improvements.
- Early identification and management of risk factors are critical.
Implications:
- Reducing stroke-related death and disability is achievable through risk factor modification.
- Improved treatment and control of hypertension, diabetes, and atrial fibrillation are paramount.
- Public health initiatives should focus on raising awareness and improving access to care for women's cardiovascular health.
Aims:
The aim of this article is to provide an overview of stroke in women and describe modifiable and non-modifiable risk factors for stroke.
Data Synthesis:
Data supporting this article come from the National Center for Health Statistics, from American Heart Association publications, and from some of the large, multicenter trials and observational studies that inform guidelines for prevention of stroke. These data indicate that stroke is the third leading cause of death in women, that risk for stroke rises rapidly with age, and that the strongest risk factors for stroke are high blood pressure and atrial fibrillation, as well as diabetes and smoking. Risk rises rapidly when two or more risk factors are present. Hormone therapy in postmenopausal women increases risk of ischemic, but not hemorrhagic stroke, by 40-50%. Biomarkers of inflammation are associated with stroke risk. Other risk factors include certain lipids, physical inactivity, and low potassium diets. Although there has been improvement in the past decade, control of hypertension is inadequate in older women and many strokes could be prevented by better treatment of hypertension.
Conclusion:
Death and disability from stroke can be reduced with modification, treatment, and better control of risk factors like hypertension, diabetes and atrial fibrillation.
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