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Does perinatal asphyxia contribute to neurological dysfunction in preterm infants?

Patricia A M van Iersel1, Saskia C M Bakker, Arnold J H Jonker

  • 1Gelre Hospital, Department of Physical Therapy, Apeldoorn, The Netherlands. pat.iersel@planet.nl

Early Human Development
|July 8, 2010
PubMed

Insights

Perinatal asphyxia did not increase neurodevelopmental risks in preterm infants. However, respiratory issues were linked to periventricular leukomalacia and poor neurological outcomes.

Area of Science:

  • Neonatal neurology
  • Developmental pediatrics

Background:

  • Preterm infants face higher risks of neurodevelopmental disorders.
  • The specific impact of perinatal asphyxia on these risks remains debated.

Purpose of the Study:

  • To assess perinatal asphyxia's role in neurological dysfunction in preterm infants.
  • To determine the association between perinatal asphyxia and cerebral palsy development.

Main Methods:

  • Studied 17 preterm infants with perinatal asphyxia and 34 matched controls.
  • Assessed neuromotor outcomes using general movements (GM) assessments at multiple time points.
  • Followed infants until 18 months corrected age for cerebral palsy diagnosis.

Main Results:

  • No significant difference in GM quality between infants with and without asphyxia.
  • Abnormal GMs linked to respiratory problems, periventricular leukomalacia (PVL), but not perinatal asphyxia.
  • Perinatal asphyxia was not associated with cerebral palsy (CP) development.

Conclusions:

  • Perinatal asphyxia does not elevate neurodevelopmental risks, including CP, in preterm infants.
  • Neonatal respiratory problems correlate with PVL and adverse neurological outcomes.
  • CP development is linked to PVL and abnormal fidgety GM.
Abstract

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