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Related Experiment Video

Updated: Jun 11, 2026

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

Published on: January 10, 2019

Optical coherence tomography (OCT) in optic neuritis and multiple sclerosis.

C Lamirel¹, N J Newman, V Biousse

¹Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, USA.

Revue Neurologique

|July 8, 2010

Summary

Optical coherence tomography (OCT) is a non-invasive eye imaging method. OCT provides key measurements for diagnosing optic neuropathies and multiple sclerosis, now used in clinical trials.

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Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

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Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

Area of Science:

Ophthalmology
Neuroscience
Medical Imaging

Background:

Optical coherence tomography (OCT) is a standard non-invasive imaging technique in ophthalmology.
OCT visualizes and quantifies retinal layers, optic nerve head topography, and macular volume.
These OCT parameters correlate with axonal loss, proving valuable in neurological conditions.

Purpose of the Study:

To highlight the utility of OCT in ophthalmology and neurology.
To emphasize the role of OCT measurements in diagnosing optic neuropathies and multiple sclerosis.
To establish OCT parameters as crucial endpoints in neurologic clinical trials.

Main Methods:

Utilizing Optical coherence tomography (OCT) for high-resolution, cross-sectional imaging of the retina.
Analyzing optic nerve head topography and peripapillary retinal nerve fiber layer thickness.
Quantifying macular volume and correlating these measurements with axonal loss.

Main Results:

OCT successfully visualizes and quantifies retinal layer morphology.
Measurements of optic nerve head topography and retinal nerve fiber layer thickness are obtained.
Macular volume data is acquired and correlated with axonal loss.

Conclusions:

OCT is a versatile tool in ophthalmology for detailed retinal analysis.
OCT parameters are significant indicators in optic neuropathies and multiple sclerosis.
OCT measurements are validated as effective endpoints for neurologic clinical trials.