Related Experiment Video
Updated: Jun 9, 2026

Experimental Protocol for Examining Behavioral Response Profiles in Larval Fish: Application to the Neuro-stimulant Caffeine
Published on: July 24, 2018
Effects of moderate exercise on the pharmacokinetics of caffeine
K Collomp1, F Anselme, M Audran
1Service d'Exploration fonctionnelle Respiratoire, Hôpital Aiguelongue, Montpellier, France.
Abstract:
The effect of moderate exercise on the kinetics of caffeine in 12 healthy volunteers-6 heavy coffee drinkers (HD) and 6 light coffee drinkers (LD) has been studied. Kinetics at Rest was measured first (R): the subjects remained at rest for 8 h after a single 250 mg dose of caffeine. One week later, the Exercise Kinetics (E) was measured under the same conditions, but with the subjects performing moderate exercise (30% of VO2 max) during the first hour of the study. Exercise raised the maximal plasma caffeine concentrations (R: 7.28: E: 10.45) and reduced both the half-life (R 3.99 h: E 2.29 h) and the volume of distribution (R 37 l: E 20.9 l). Both during exercise and at rest. HD had a greater half-life elimination and volume of distribution than LD. The results suggest potentiation of the effects of caffeine during exercise and an increase in its distribution due to regular heavy coffee intake.
More Related Videos
09:11Caffeine Extraction, Enzymatic Activity and Gene Expression of Caffeine Synthase from Plant Cell Suspensions
Published on: October 2, 2018
07:26Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
Published on: October 17, 2018
Related Concept Videos
Time Course of Drug Effect
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug