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Updated: Jun 11, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Synthesis and antimicrobial activity of some new thiazole, thiophene and pyrazole derivatives containing
Samir Bondock1, Walid Fadaly, Mohamed A Metwally
1Department of Chemistry, Faculty of Science, Mansoura University, ET-35516 Mansoura, Egypt. Bondock@mans.edu.eg
Abstract:
In an attempt to find a new class of antimicrobial agents, a series of thiazole, thiophene, pyrazole and other related products containing benzothiazole moiety were prepared via the reaction of N-(benzothiazol-2-yl)-2-cyanoacetamide (1) with appropriate chemical reagents. These compounds were screened for their antibacterial activity against gram-positive bacteria (Staphylococcus aureus and Streptococcus pyogenes), gram-negative bacteria (Pseudomonas phaseolicola and Pseudomonas fluorescens) and antifungal activity against Fusarium oxysporum and Aspergillus fumigatus. Among the synthesized compounds, thiophene 13 showed equal activity with chloroamphenicol against S. aureus (MIC 3.125 microg/mL), while its activity was 50% lower than of chloroamphenicol against S. pyogenes. Thiazole 3 and pyrazolo[1,5-a]pyrimidine 21 b were found to exhibit the most potent in vitro antifungal activity with MICs (6.25 microg/mL) against A. fumigatus and F. oxysporum. Structures of the newly synthesized compounds were established by elemental analysis and spectral data.
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