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Related Experiment Videos

Phosphatidylserine reverses the age-dependent decrease in cortical acetylcholine release: a microdialysis study.

F Casamenti1, C Scali, G Pepeu

  • 1Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.

European Journal of Pharmacology
|February 26, 1991
PubMed
Summary
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Phosphatidylserine (PtdSer) supplementation may improve acetylcholine (ACh) release in aging rats. This study found PtdSer attenuated age-related declines in ACh and choline (Ch) output in the parietal cortex.

Area of Science:

  • Neuroscience
  • Aging Research
  • Biochemistry

Background:

  • Acetylcholine (ACh) is a crucial neurotransmitter involved in cognitive functions.
  • Age-related decline in ACh levels is associated with cognitive impairment.
  • Choline (Ch) availability is a key factor in ACh synthesis.

Purpose of the Study:

  • To investigate the effect of aging on basal acetylcholine and choline output in the rat parietal cortex.
  • To evaluate the potential of phosphatidylserine (PtdSer) supplementation to counteract age-related changes in ACh and Ch levels.

Main Methods:

  • Microdialysis was used to measure in vivo basal ACh and Ch output from the parietal cortex of 3- and 19-month-old rats.
  • ACh and Ch concentrations were quantified using High-Performance Liquid Chromatography (HPLC) with electrochemical detection.

Related Experiment Videos

  • Rats were treated with PtdSer, phosphatidylcholine (PtdCho), o-phospho-dl-serine (P-Ser), or Tris buffer.

    • Main Results:

    • 19-month-old rats exhibited significantly lower basal ACh and Ch output compared to 3-month-old rats.
    • Chronic PtdSer administration (15 mg/kg daily for 8 days) attenuated the age-related decrease in ACh release in older rats.
    • PtdSer treatment did not affect ACh and Ch output in younger rats.
    • Neither PtdCho nor P-Ser administration reversed the age-related decline in ACh and Ch output.

    Conclusions:

    • Aging is associated with reduced basal acetylcholine and choline release in the parietal cortex.
    • Phosphatidylserine (PtdSer) supplementation may represent a viable strategy to improve cholinergic function in aging.
    • PtdSer might enhance ACh release by increasing choline availability for synthesis in aged rats.