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Down-regulation of a kinase defective PKC-alpha
1Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, London, UK.
FEBS Letters
|June 17, 1991
Abstract:
A kinase defective mutant of PKC-alpha down-regulates in response to phorbol esters as effectively as the wild-type protein when introduced into COS-1 cells. This demonstrates that intramolecular autophosphorylation is not a prerequisite for down-regulation.