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Published on: October 12, 2017

Decreased serum fetuin-A levels are associated with coronary artery diseases

Oktay Bilgir1, Levent Kebapcilar, Ferda Bilgir

  • 1Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey.

Internal Medicine (Tokyo, Japan)
|July 8, 2010
PubMed

Insights

Serum fetuin-A levels were lower in patients with stable angina and myocardial infarction, suggesting a role in coronary artery disease (CAD) pathophysiology. Soluble adhesion molecules were not significantly related to CAD.

Area of Science:

  • Cardiology
  • Biochemistry
  • Immunology

Background:

  • Acute coronary syndrome (ACS) involves complex pathophysiological processes.
  • Biomarkers are crucial for understanding and diagnosing ACS.
  • Fetuin-A and soluble cellular adhesion molecules are potential biomarkers.

Purpose of the Study:

  • To investigate serum Fetuin-A levels.
  • To analyze soluble intercellular adhesion molecule-1 (sICAM-1) and vascular cellular adhesion molecule-1 (sVCAM-1) levels.
  • To correlate these levels with acute coronary syndrome (ACS).

Main Methods:

  • Serum samples were collected from 127 patients presenting with chest pain.
  • Patients were categorized into stable angina (SA), myocardial infarction (MI), and non-cardiac groups.
  • Fetuin-A levels were logarithmically transformed for analysis.

Main Results:

  • Log-Fetuin-A levels were higher in non-cardiac subjects than in MI and SA patients (p<0.05).
  • SA patients had lower Fetuin-A levels than controls but higher than MI patients.
  • sVCAM-1 and sICAM-1 levels did not differ between patients with coronary atherosclerosis and non-cardiac subjects.

Conclusions:

  • Serum sVCAM-1 and sICAM-1 levels are not associated with coronary artery disease (CAD).
  • Fetuin-A levels appear decreased in SA and MI patients.
  • Reduced fetuin-A may contribute to the pathophysiology of CAD.
Abstract

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