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Antigen receptor-mediated calcium signals in B cells as revealed by confocal fluorescence microscopy
H Yamada1, J Mizuguchi, M Nakanishi
1Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
FEBS Letters
|June 24, 1991
Abstract:
A confocal fluorescence microscope was used to study the antigen receptor-mediated calcium signals in B cells. Anti-IgD binding to B lymphoma cells (BAL17) increased the intracellular calcium concentration with short lag times. Confocal fluorescence images of the fluo-3-loaded BAL17 cells showed that the intracellular calcium ion concentrations increased non-homogeneously, suggesting that the calcium signals transferred not only to the cytoplasm but also to the nucleus.