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Related Experiment Video

Updated: Jun 11, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

[Toxic hepatitis associated with Polygoni multiflori].

Sang Hoon Bae¹, Dong Hyun Kim, Young Seok Bae

¹Department of Internal Medicine, Good Samsun Hospital, Korea. baesh96@hanmail.net

The Korean Journal of Hepatology

|July 8, 2010

Summary

This summary is machine-generated.

Herbal remedies like Ho-Shou-Wu can cause toxic hepatitis, a serious liver condition. This case highlights the importance of considering supplements when diagnosing acute hepatitis.

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Published on: December 2, 2022

Area of Science:

Hepatology
Toxicology
Integrative Medicine

Background:

Toxic hepatitis is a significant cause of acute liver injury.
The role of herbal remedies and health foods in drug-induced liver injury (DILI) is often underestimated.
Polygoni multiflori (Ho-Shou-Wu) is a traditional Chinese herb with potential hepatotoxic effects.

Observation:

A 54-year-old woman developed toxic hepatitis after consuming Ho-Shou-Wu for one month.
Symptoms included fatigue and weakness, with diagnosis confirmed by clinical history, laboratory data, and ultrasonography.
Liver function improved upon discontinuation of Ho-Shou-Wu but rapidly worsened upon re-consumption.

Findings:

The patient's clinical presentation and the herb's withdrawal and re-challenge strongly suggest Polygoni multiflori as the causative agent of toxic hepatitis.
The case demonstrates a clear correlation between Ho-Shou-Wu intake and the onset and recurrence of liver injury.
Koch's postulates were effectively satisfied, confirming the herb's role in the observed hepatitis.

Implications:

Highlights the potential hepatotoxicity of commonly used herbal products like Ho-Shou-Wu.
Emphasizes the need for increased clinical awareness and investigation of herbal remedies in cases of unexplained acute hepatitis.
Suggests that healthcare providers should inquire about supplement use in patients presenting with liver dysfunction.