Nondermatophytic moulds as a causative agent of onychomycosis in tehran

In the last few years the number of cases of nondermatophytic onychomycosis has greatly increased.

To evaluate the incidence, the clinic characteristics, and predisposing factors of nondermatophytic onychomycosis.

All collected specimens were analyzed by direct microscopy and culture. Microscopic examination of these specimens was carried out in potassium hydroxide solution (20%) with dimethyl sulfoxide (4%). These specimens were cultured on sabouraud's glucose agar with chloramphenicol and sabouraud's glucose agar with chloramphenicol and cycloheximide. Cultures were incubated at 25 degrees C for up to 28 days and checked twice weekly for growth.

Nondermatophytic onychomycosis were 11.5% of all onychomycosis. We found that Aspergillus spp. were the more responsible etiologic agents of nondermatophytic onychomycosis, resulting in a total of 28 patients (59.6%). In our study other causative agents were Acremonium spp. (17%), Fusarium spp. (12.7%), Geotrichum spp. (4.2%), Trichosporun spp., (4.2%) and Scopulariopsis spp (2.1%). In our patients moulds onychomycosis developed mainly in toenails (74.5%).

Knowing the exact pathogen is important and has implications in therapy and prognosis.