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Leishmaniasis

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Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...

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Updated: Jun 11, 2026

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

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Published on: February 20, 2020

A current perspective on leishmaniasis.

¹Department of Global Health, MDC 56 College of Public Health, 12901 Bruce B Downs Blvd, Tampa, USA.

Journal of Global Infectious Diseases

|July 8, 2010

Summary

This summary is machine-generated.

Controlling leishmaniasis, a disease affecting impoverished regions, faces significant hurdles. This review explores the global burden, current control strategies, and emerging treatments for cutaneous and visceral leishmaniasis.

Keywords:

Cutaneous leishmaniasis Treatments Vaccines Visceral leishmaniasis

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In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

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Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

Area of Science:

* Infectious Diseases
* Global Health
* Parasitology

Background:

* Leishmaniasis remains endemic in impoverished and conflict-affected regions globally.
* Successful control and eradication efforts are hindered by numerous challenges.

Purpose of the Study:

* To examine the global disease burden of cutaneous and visceral leishmaniasis.
* To discuss current World Health Organization surveillance and control measures.
* To review potential novel treatments and vaccines for leishmaniasis.

Main Methods:

* Extensive literature review.
* Analysis of global disease burden data.
* Review of WHO control strategies and emerging therapies.

Main Results:

* Leishmaniasis presents a substantial global health burden, particularly in vulnerable populations.
* Current control measures face challenges in implementation and efficacy.
* Promising advancements in treatments and vaccine development are underway.

Conclusions:

* Addressing the multifaceted challenges of leishmaniasis requires integrated global efforts.
* Continued research into novel therapeutics and preventative vaccines is crucial.
* Enhanced surveillance and control strategies are vital for disease eradication.