Related Experiment Video

Updated: Jun 11, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

Neuropathologic and clinical features of human medial temporal lobe epilepsy

Eun-Kee Bae1, Keun-Hwa Jung, Kon Chu

  • 1Stroke & Stem Cell Laboratory in Clinical Research Institute, Stem Cell Research Center, Department of Neurology, Seoul National University, Seoul, Korea.

Journal of Clinical Neurology (Seoul, Korea)
|July 8, 2010
PubMed
Abstract

Insights

Cell genesis in the hippocampus of patients with medial temporal lobe epilepsy (mTLE) correlates with granule cell dispersion (GCD) and is influenced by childhood febrile seizures and generalized seizure frequency.

Area of Science:

  • Neuroscience
  • Neuropathology
  • Epilepsy Research

Background:

  • Medial temporal lobe epilepsy (mTLE) is associated with hippocampal morphological changes in rodents.
  • Human hippocampal changes in mTLE, including neuronal loss, cell genesis, and granule cell dispersion (GCD), are not well understood.

Purpose of the Study:

  • To investigate histological changes in surgical hippocampal specimens from mTLE patients.
  • To analyze neuronal loss, cell genesis, and GCD in human mTLE hippocampi.

Main Methods:

  • Histological analysis of human hippocampal specimens from medically intractable mTLE patients.
  • Nissl staining for neuronal loss, nestin and Prox1 immunohistochemistry for cell genesis and GCD.
  • Correlation analysis between clinical parameters and histopathological findings.

Main Results:

  • Cell genesis in the granule cell layer significantly correlated with GCD severity.
  • Cell genesis was associated with a history of childhood febrile seizures and frequent generalized seizures.
  • No correlation found between cell genesis and cell death, age at seizure onset, epilepsy duration, or mean overall seizure frequency.

Conclusions:

  • Cell genesis in the dentate gyrus of mTLE patients is linked to GCD.
  • Childhood febrile seizures and generalized seizure frequency influence cell genesis in mTLE hippocampi.
Keywords:
dentate gyrusepilepsyhippocampuspathologytemporal lobe

More Related Videos

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures12:30

A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures

Published on: July 2, 2014

Related Concept Videos

Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...