Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Determination of Crystal Structures

Determination of Crystal Structures

In the late 1800s, the revelation that light extended beyond visible wavelengths led to the discovery of X-rays by Wilhelm Roentgen. Recognized as high-energy electromagnetic radiation with short wavelengths, X-rays prompted exploration into their interaction with crystals. Max von Laue proposed in 1912 that the periodic arrangement of atoms, ions, or molecules in crystals would cause them to diffract X-rays, a hypothesis confirmed through experiments with copper sulfate and zinc sulfide...

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Assessing variations in 3D image quality in chest CT across sites and scanners.

Medical physics·2026

Same author

Skeletal Muscle Ultrasound Radiomics and Machine Learning for the Earlier Detection of Type 2 Diabetes Mellitus.

Journal of medical ultrasound·2025

Same author

Thorax-encompassing multi-modality PET/CT deep learning model for resected lung cancer prognostication: A retrospective, multicenter study.

Medical physics·2025

Same author

Deep Rib Fracture Instance Segmentation and Classification From CT on the RibFrac Challenge.

IEEE transactions on medical imaging·2025

Same author

Fracture and Fragmentation of Vascular Calcifications by Focused Ultrasound.

Journal of cardiovascular translational research·2025

Same author

Virtual imaging trials in medicine: A brief takeaway of the lessons from the first international summit.

Medical physics·2024

Search research articles

Related Experiment Video

Updated: Jun 11, 2026

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

Determining Block Detector Positions for PET Scanners.

Larry Pierce¹, Robert Miyaoka, Tom Lewellen

¹University of Washington, Seattle, WA. 98195.

IEEE Nuclear Science Symposium Conference Record. Nuclear Science Symposium

|July 8, 2010

Summary

This summary is machine-generated.

This study introduces an algorithm for precise block detector localization in positron emission tomography (PET) scanners. Accurate positioning improves image quality by correcting errors in line-of-response (LOR) calculations.

More Related Videos

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT

Functional Imaging of Brown Fat in Mice with ¹⁸F-FDG micro-PET/CT

Published on: November 23, 2012

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

Related Experiment Videos

Last Updated: Jun 11, 2026

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT

Functional Imaging of Brown Fat in Mice with ¹⁸F-FDG micro-PET/CT

Published on: November 23, 2012

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

Area of Science:

Medical Imaging
Nuclear Physics
Instrumentation

Background:

Accurate positron emission tomography (PET) image reconstruction relies on precise detector positioning.
Manufacturing tolerances can lead to errors in block detector placement and orientation.
These errors propagate to the line-of-response (LOR) positioning, degrading image quality.

Purpose of the Study:

To develop and present an algorithm for accurate localization of block detectors in PET scanners.
To address the impact of detector positioning tolerances on image reconstruction accuracy.
To improve the fidelity of reconstructed PET images.

Main Methods:

Utilized a rotating point source phantom to determine detector block locations.
Measured scintillator crystal positions within detector blocks based on phantom rotation.
Applied aggregate block positions to the system model for precise LOR determination.

Main Results:

Successfully determined the precise location and orientation of block detectors.
Enabled accurate calculation of the true line-of-response (LOR) positions.
Demonstrated improved image fidelity in reconstructions using the accurate LOR data.

Conclusions:

The developed algorithm effectively compensates for detector positioning errors in PET scanners.
Precise LOR positioning derived from accurate detector localization significantly enhances PET image quality.
This method offers a pathway to improved diagnostic accuracy in PET imaging.