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Secretin attenuates the hereditary repetitive hyperactive movements in a mouse model
Katalin Köves1, Gusztav Kiss, Andrea Heinzlmann
1Department of Human Morphology and Developmental Biology, Semmelweis University, Tűzoltó u. 58, Budapest H-1094, Hungary. koves@ana2.sote.hu
Journal of Molecular Neuroscience : MN
|July 8, 2010
Summary
Secretin administration in Japanese waltzing mice reduced stereotypic movements and normalized ambulation. This peptide hormone improved horizontal movement but did not affect exploratory behaviors like rearing and jumping.
Area of Science:
- Neuroscience
- Animal Behavior
- Pharmacology
Background:
- Secretin's influence on rat behavior via open-field testing is established.
- Japanese waltzing mice exhibit characteristic stereotypic circular movements.
Purpose of the Study:
- To compare the effects of intracerebroventricular secretin on CFLP white and Japanese waltzing mice.
- To investigate secretin's impact on horizontal (ambulation) and vertical (rearing, jumping) movements in an open-field test.
Main Methods:
- Intracerebroventricular administration of 2 μg secretin in mice.
- Behavioral analysis using the open-field test over 30 minutes.
- Comparison of ambulation, rearing, and jumping between CFLP white and Japanese waltzing mice.
Main Results:
- Japanese waltzing mice showed less ambulation and rearing/jumping than CFLP white mice.
- Secretin did not affect white mice's behavior.
- In waltzing mice, secretin increased ambulation time and distance to levels seen in white mice.
- Secretin did not alter rearing or jumping in waltzing mice.
Conclusions:
- Intracerebroventricular secretin attenuates stereotypic movements in Japanese waltzing mice.
- Secretin improves horizontal movement by normalizing ambulation in this model.
- Secretin does not influence exploratory behaviors (rearing, jumping) in Japanese waltzing mice.
