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Cloning of nocardioform DNA conferring the ability to inactivate rifampicin
1Department of Genetics, University of the Witwatersrand, Johannesburg, Republic of South Africa.
FEMS Microbiology Letters
|April 15, 1991
Abstract:
A novel mechanism of resistance to rifampicin has recently been reported in which this antibiotic is inactivated. Here we describe the cloning of DNA from a nocardiofrom strain conferring this ability to inactivate rifampicin. Cloning was on the basis of complementation, as an increased resistance to the antibiotic. The genetic information was on a 8.3-kb BglII fragment.