Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 11, 2026

Transthoracic Echocardiographic Examination in the Rabbit Model
14:46

Transthoracic Echocardiographic Examination in the Rabbit Model

Published on: June 1, 2019

Morphologic changes and methodological issues in the rabbit experimental model for diaphragmatic hernia.

Xenia I Roubliova1, Jan A Deprest, Jean Marc Biard

  • 1Center for Surgical Technologies, Faculty of Medicine, Katholieke Universitet, Leuven, Belgium.

Histology and Histopathology
|July 8, 2010
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Blood biomarkers for the diagnosis of chorioamnionitis following preterm premature rupture of membranes: a systematic review and meta-analysis of studies since 2020.

Critical reviews in clinical laboratory sciences·2026
Same author

Long-Term Locoregional Control and Pattern of Recurrences After Implementation of Highly Conformal Flank Target Volumes and Image-Guided Intensity Modulated Arc Therapy for Pediatric Wilms Tumors.

International journal of radiation oncology, biology, physics·2026
Same author

Impact of first-trimester preeclampsia screening on perinatal and maternal morbidity: the RANSPRE open multicenter randomized trial.

BMC pregnancy and childbirth·2026
Same author

Determinents of spontaneous labor for prolonged pregnancy and effectiveness of membrane sweeping: An observational study.

Journal of gynecology obstetrics and human reproduction·2026
Same author

Differential expression of ADAM10 in fetal membranes during pregnancy and evaluation as an early blood biomarker for preterm birth.

Journal of reproductive immunology·2026
Same author

Molecular Features Associated with a High-Risk Clinical Course in Neuroblastomas Initially Diagnosed as Non-High-Risk.

Cancers·2026

Congenital diaphragmatic hernia (CDH) causes severe lung hypoplasia. In this rabbit model, CDH significantly reduced lung development and airway structures, with fixation pressure having minimal impact on severely affected lungs.

Area of Science:

  • Developmental biology
  • Comparative pathology
  • Respiratory system research

Background:

  • Fetal lung development can be compromised by congenital anomalies like congenital diaphragmatic hernia (CDH).
  • Isolated CDH leads to significant mortality due to lung hypoplasia and pulmonary hypertension.
  • Animal models are crucial for understanding CDH pathophysiology and testing therapies.

Purpose of the Study:

  • To investigate the impact of surgically induced congenital diaphragmatic hernia (CDH) on fetal lung development in a rabbit model.
  • To evaluate the effects of different fixation pressures on morphometric analysis of hypoplastic lungs.

Main Methods:

  • Congenital diaphragmatic hernia (CDH) was surgically created in fetal rabbits at day 23 of gestation.
  • Lungs were harvested at term (day 30) and fixed with or without pressure (25 cm H2O).

More Related Videos

Model of Ischemia and Reperfusion Injury in Rabbits
06:11

Model of Ischemia and Reperfusion Injury in Rabbits

Published on: November 3, 2023

Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration
05:20

Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration

Published on: March 31, 2023

Related Experiment Videos

Last Updated: Jun 11, 2026

Transthoracic Echocardiographic Examination in the Rabbit Model
14:46

Transthoracic Echocardiographic Examination in the Rabbit Model

Published on: June 1, 2019

Model of Ischemia and Reperfusion Injury in Rabbits
06:11

Model of Ischemia and Reperfusion Injury in Rabbits

Published on: November 3, 2023

Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration
05:20

Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration

Published on: March 31, 2023

  • Lung-to-body weight ratio (LBWR), airway morphometry, and vascular morphometry were analyzed.

    • Main Results:

    • Surgically induced CDH resulted in significant lung hypoplasia, with ipsilateral lungs showing reduced weight and airway generations (terminal bronchioles).
    • Ipsilateral CDH lungs exhibited thickened media in peripheral arteries.
    • Fixation pressure had no significant effect on morphometric indices in severely hypoplastic, unventilated lungs, unlike in control lungs.

    Conclusions:

    • Congenital diaphragmatic hernia (CDH) severely impairs fetal lung development, affecting airway structure and vascularization.
    • Lung fixation pressure does not significantly alter morphometric measurements in severely hypoplastic lungs.
    • These findings highlight the structural deficits in CDH lungs and the limitations of pressure-based fixation for assessing hypoplastic lung development.