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Updated: Jun 11, 2026

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Published on: September 2, 2015

Controlled induction of distributed microdeformation in wounded tissue via a microchamber array dressing.

Bartholomew J Kane¹, George Younan, Douglas Helm

¹Division of Pediatric Surgery, Department of Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA.

Journal of Biomedical Materials Research. Part A

|July 8, 2010

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Researchers developed a novel microfabricated dressing to control mechanical stimulation in dermal wound healing. This device precisely deforms wounded tissue, enabling advanced mechanobiology studies.

Area of Science:

Biotechnology
Tissue Engineering
Biomedical Engineering

Background:

Mechanical stimuli significantly influence cell and tissue structure and function.
Mechanical signals are increasingly recognized for their role in mammalian dermal wound healing.
Understanding the cellular response to mechanical stimulation in wounded tissue is crucial but limited by current instrumentation.

Purpose of the Study:

To test the hypothesis that a microfabricated dressing can control induced wound tissue deformation.
To develop instrumentation for applying controlled mechanical stimuli to wounded tissue for mechanobiology research.

Main Methods:

A microfabricated dressing with hexagonally shaped microchambers made of silicone rubber was designed.
The dressing was applied to full-thickness murine dermal wounds and connected to a vacuum source (200 mmHg for 12 h).

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Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

Published on: February 26, 2015

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Last Updated: Jun 11, 2026

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Published on: September 2, 2015

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

Published on: February 26, 2015

Tissue deformation was measured, and its relationship with microchamber dimensions (height and width) was statistically analyzed.

Main Results:

The microfabricated dressing successfully induced wound tissue deformation ranging from 11% to 29%.
Statistical analysis confirmed that the magnitude of induced deformation is dependent on microchamber height and width.
The dressing demonstrated the ability to control the extent of mechanical deformation applied to the underlying tissue.

Conclusions:

The developed microfabricated dressing effectively controls mechanical stimulation intensity in dermal wound healing.
This innovative device facilitates sophisticated mechanobiology studies by allowing variable mechanical stimulation.
The findings pave the way for a deeper understanding of mechanotransduction in wound repair.