The evolution of oxidative stress indicators in the course of myocardial ischemia

Two studies were carried out in patients suffering from Unstable Angina (UA) and Myocardial Infarction (MI). The first study investigated the variations of the Malondialdehyde (MDA) rate at 1st, 5th, 12th day of treatment in 27 patients (15 UA and 12 MI), compared to 15 controls. This rate varied in a different way, with a first peak and a rapid decrease in UA, where it regularly decreases in MI. The second study focused on the variations of MDA, Superoxide Dismutase (SOD), Glutathion Peroxydase (GPX) rates at 2nd, 12th days in 53 patients (19 UA and 34 MI), compared to 35 controls. Here again, the rate of MDA was high on day 2 and decreased on day 12. The rate of GPX showed similar evolution while the SOD rate had an opposite evolution. These two studies confirm the evidence of oxidative stress in acute coronary deficiency.