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Related Experiment Video

Updated: Jun 11, 2026

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

Epigenetic regulation in neural stem cell differentiation.

Berry Juliandi¹, Masahiko Abematsu, Kinichi Nakashima

¹Laboratory of Molecular Neuroscience, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan.

Development, Growth & Differentiation

|July 9, 2010

Summary

Epigenetic regulation and transcription factors control neural stem cell (NSC) differentiation into specific central nervous system (CNS) cell types. Understanding these mechanisms is key for clinical applications involving NSC therapies.

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Last Updated: Jun 11, 2026

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

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Published on: June 3, 2016

Efficient Neural Differentiation using Single-Cell Culture of Human Embryonic Stem Cells

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Published on: January 18, 2020

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

Area of Science:

Neuroscience
Developmental Biology
Epigenetics

Background:

The central nervous system (CNS) develops from multipotent neural stem cells (NSCs) differentiating into neurons, astrocytes, and oligodendrocytes.
NSC differentiation is a spatiotemporally regulated process during mammalian development.
Epigenetic regulation plays a crucial role in modulating NSC fate, interacting with transcription factors and environmental signals.

Purpose of the Study:

To review recent findings on molecular mechanisms regulating NSC fate specification.
To focus on epigenetic and transcription factor-mediated regulation during mammalian forebrain development.

Main Methods:

Literature review of recent research findings.
Analysis of molecular mechanisms of epigenetic and transcription factor-mediated regulation.
Focus on the developing mammalian forebrain.

Main Results:

Epigenetic mechanisms are integral to cell-intrinsic programs governing NSC differentiation.
Transcription factors and environmental cues interact with epigenetic regulators.
Specific molecular pathways dictate the fate of NSCs into distinct CNS cell types.

Conclusions:

Epigenetic and transcription factor-mediated regulation are critical for specifying NSC fate during CNS development.
This regulatory network offers potential for clinical applications utilizing NSC differentiation.
Further research into these mechanisms, particularly in the mammalian forebrain, is warranted.