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Related Experiment Video

Updated: Jun 11, 2026

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

Published on: October 2, 2020

Two variable sodium profiles and adverse effects during hemodialysis: a randomized crossover study.

Fernanda S Meira¹, Ana E Figueiredo, Juscelino Zemiarcki

¹Department of Internal Medicine, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

|July 9, 2010

Summary

Sodium profiling in hemodialysis reduced adverse events like hypotension and cramps. Both step and linear profiles were effective, but individual patient responses varied, necessitating personalized evaluation.

Related Experiment Videos

Last Updated: Jun 11, 2026

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

Published on: October 2, 2020

Area of Science:

Nephrology
Clinical Trials
Dialysis Technology

Background:

Intradialytic symptomatic hypotension and muscle cramps are common issues for hemodialysis patients.
Sodium profiling is a potential strategy to mitigate these adverse effects during dialysis.

Purpose of the Study:

To compare the incidence of intradialytic adverse events and changes in physiological variables using no sodium profiling versus two distinct sodium profiles (step and linear).

Main Methods:

A prospective, randomized crossover study involving 22 hemodialysis patients.
Patients received a 12-session control period followed by 12 sessions of either a step or linear dialysate sodium profile, with a crossover after a wash-out period.
Data collected included adverse event frequency, interdialytic weight gain, and pre- and post-dialysis blood pressure.

Main Results:

The overall frequency of intradialytic adverse effects was significantly lower with both step (33.7%) and linear (36.0%) sodium profiling compared to the control period (48.5%).
Post-dialysis systolic blood pressure was significantly lower during the linear sodium profile period.
While seven patients benefited, two experienced increased symptoms, indicating variable patient response to sodium profiling.

Conclusions:

Both step and linear dialysate sodium profiling effectively reduce the frequency of intradialytic adverse effects in hemodialysis.
The step profile was associated with less intradialytic hypotension, and the linear profile showed a trend towards fewer cramps.
Sodium profiling's benefit is patient-specific and requires individual assessment for optimal outcomes.