Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Small-molecule modulators of HIPK4 activity and proteostasis.

bioRxiv : the preprint server for biology·2026
Same author

Macrocyclization of Broad-Spectrum Kinase Inhibitor Bosutinib leads to Potent and Selective Quinoline-based HIPK4 Inhibitor AZ137.

bioRxiv : the preprint server for biology·2026
Same author

Mitochondrial DNA Dysfunction in Cardiovascular Diseases: A Novel Therapeutic Target.

Antioxidants (Basel, Switzerland)·2025
Same author

Therapeutic connections between pyroptosis and paclitaxel in anti-tumor effects: an updated review.

Naunyn-Schmiedeberg's archives of pharmacology·2025
Same author

Evaluation of Benzo[cd]indol-2(1H)-ones as Downstream Hedgehog Pathway Inhibitors.

ChemistryOpen·2025
Same author

Current developments of pharmacotherapy targeting heme oxygenase 1 in cancer (Review).

International journal of oncology·2025

Related Experiment Video

Updated: Jun 11, 2026

A Semi-high-throughput Imaging Method and Data Visualization Toolkit to Analyze C. elegans Embryonic Development
06:49

A Semi-high-throughput Imaging Method and Data Visualization Toolkit to Analyze C. elegans Embryonic Development

Published on: October 29, 2019

Synthetic strategies for studying embryonic development.

Xiaohu Ouyang1, James K Chen

  • 1Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Chemistry & Biology
|July 9, 2010
PubMed
Summary

Synthetic biology tools like chemical probes and engineered proteins precisely investigate embryonic development. This review explores their use in manipulating DNA, RNA, and proteins to understand developmental mechanisms.

More Related Videos

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
07:34

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

Published on: February 16, 2017

Manipulation and In Vitro Maturation of Xenopus laevis Oocytes, Followed by Intracytoplasmic Sperm Injection, to Study Embryonic Development
09:22

Manipulation and In Vitro Maturation of Xenopus laevis Oocytes, Followed by Intracytoplasmic Sperm Injection, to Study Embryonic Development

Published on: February 9, 2015

Related Experiment Videos

Last Updated: Jun 11, 2026

A Semi-high-throughput Imaging Method and Data Visualization Toolkit to Analyze C. elegans Embryonic Development
06:49

A Semi-high-throughput Imaging Method and Data Visualization Toolkit to Analyze C. elegans Embryonic Development

Published on: October 29, 2019

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
07:34

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

Published on: February 16, 2017

Manipulation and In Vitro Maturation of Xenopus laevis Oocytes, Followed by Intracytoplasmic Sperm Injection, to Study Embryonic Development
09:22

Manipulation and In Vitro Maturation of Xenopus laevis Oocytes, Followed by Intracytoplasmic Sperm Injection, to Study Embryonic Development

Published on: February 9, 2015

Area of Science:

  • Developmental Biology
  • Synthetic Biology
  • Molecular Mechanisms

Background:

  • Developmental biology has transitioned from descriptive to mechanistic, driven by molecular biology and genetics.
  • Synthetic strategies offer precise spatial and temporal control for studying embryonic patterning.

Purpose of the Study:

  • To review the application of synthetic strategies in developmental biology.
  • To explore chemical tools and engineered proteins for perturbing developmental processes.

Main Methods:

  • Perturbation of DNA, RNA, protein, and cellular levels using chemical tools.
  • Utilizing engineered proteins for targeted manipulation of developmental pathways.
  • Analysis of design principles, capabilities, and limitations of synthetic methods.

Main Results:

  • Chemical tools and engineered proteins enable precise interrogation of embryonic development.
  • Methods allow for targeted manipulation at multiple biological levels (DNA, RNA, protein, cell).

Conclusions:

  • Synthetic biology provides powerful approaches to unravel complex developmental mechanisms.
  • Future research requires collaboration between chemical and developmental biologists to overcome limitations and advance the field.