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Hereditary hemochromatosis as a risk factor for joint replacement surgery
Enijad Sahinbegovic1, Tomás Dallos, Elmar Aigner
1Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany.
The American Journal of Medicine
|July 9, 2010
Summary
Patients with hereditary hemochromatosis have a significantly higher risk of joint replacement surgery due to secondary osteoarthritis. This condition leads to earlier and more frequent joint replacements compared to the general population.
Area of Science:
- Rheumatology
- Genetics
- Orthopedics
Background:
- Hereditary hemochromatosis is an inherited disorder characterized by iron overload.
- Joint involvement in hemochromatosis can mimic osteoarthritis.
- The impact of hemochromatosis on the need for joint replacement surgery is not well-established.
Purpose of the Study:
- To determine the rate of joint replacement surgery in individuals with hereditary hemochromatosis.
- To compare joint replacement rates in hemochromatosis patients with a healthy control group.
- To investigate the age of onset and frequency of joint replacement in hemochromatosis.
Main Methods:
- A cross-sectional cohort study was conducted.
- 199 individuals with hereditary hemochromatosis were analyzed.
- Data were compared to 917 healthy subjects from the population-based Bruneck study.
Main Results:
- 32 of 199 hemochromatosis patients underwent joint replacement surgery (52 joints replaced).
- Hemochromatosis patients had a 9-fold higher risk of joint replacement surgery (OR 9.0).
- Joint replacement occurred significantly earlier (before age 50) and more frequently in hemochromatosis patients.
Conclusions:
- Hereditary hemochromatosis is a significant risk factor for joint replacement surgery.
- Severe secondary osteoarthritis is a complication of hemochromatosis.
- Early and multiple joint replacements are more common in hemochromatosis patients.
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