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The effect of postoperative gastrointestinal complications in patients undergoing coronary artery bypass surgery
José L Díaz-Gómez1, Benjamin Nutter, Meng Xu
1Department of Cardiothoracic Anesthesia, Cleveland Clinic, Cleveland, Ohio 45195, USA. diazj@ccf.org
Insights
Gastrointestinal complications after coronary artery bypass graft surgery (CABG) are rare but significantly increase mortality. Intra-aortic balloon pump use and fresh-frozen plasma are linked to these complications, warranting further study.
Area of Science:
- Cardiovascular Surgery
- Gastrointestinal Surgery
- Critical Care Medicine
Background:
- Gastrointestinal (GI) complications following coronary artery bypass graft surgery (CABG) are infrequent but carry a high mortality risk.
- Identifying factors associated with GI complications is crucial for improving patient outcomes after CABG.
Purpose of the Study:
- To identify variables associated with postoperative GI complications in patients undergoing isolated CABG.
- To analyze the impact of these GI complications on postoperative mortality.
Main Methods:
- A 12-year retrospective analysis of patients undergoing isolated CABG was conducted using an anesthesiology registry.
- Multivariable logistic regression was employed to determine predictors of GI complications and their association with mortality.
Main Results:
- The incidence of GI complications was 1.43% (213/16,043 patients).
- Key predictors included intra-aortic balloon pump insertion (preoperative and intraoperative), patient age, intraoperative fresh-frozen plasma transfusion, and cardiogenic shock.
- Postoperative GI complications were associated with a 12.98-fold increase in mortality (p < 0.001).
Conclusions:
- GI complications after isolated CABG are rare but significantly increase the risk of death.
- Intraoperative fresh-frozen plasma and intra-aortic balloon pump use are associated with GI complications and require further investigation.
Background:
Gastrointestinal (GI) complications after coronary artery bypass graft surgery (CABG) are uncommon but associated with a disproportionate share of mortality. We thus identified variables associated with GI complications and analyzed their effect on postoperative mortality in patients undergoing isolated CABG.
Methods:
Information from patients who underwent isolated CABG at our institution during a 12-year period was obtained from the Anesthesiology Institute patient registry. Patients who experienced one or more postoperative GI complication(s) during their initial intensive care unit stay were identified. Multivariable logistic regression with backward variable selection was used to determine variables associated with GI complications and to evaluate their effect on mortality.
Results:
Among 16,043 patients who underwent isolated CABG, 213 (1.43%) had one or more GI complication(s). The main patient variables associated with postoperative GI complications included preoperative (odds ratio, 2.43; 95% confidence interval [CI], 1.39 to 4.23; p < 0.001) and intraoperative (odds ratio, 5.07; 95% CI, 3.08 to 8.35; p < 0.001) intraaortic balloon pump insertion, patient age (odds ratio, 1.65; 95% CI, 1.41 to 1.94; p < 0.001), intraoperative fresh-frozen plasma transfusion (odds ratio, 3.38; 95% CI, 2.12 to 5.41; p < 0.001), and cardiogenic shock (odds ratio, 3.04; 95% CI, 1.12 to 8.24). No difference was detected in complication rates between off-pump and on-pump CABG procedures (1.50% versus 1.30%, respectively; p = 0.63). Postoperative GI complication(s) after CABG was associated with a 12.98 times increase in mortality (p < 0.001).
Conclusions:
This single-center cohort study indicates that GI complications after isolated CABG remain rare with an incidence 1.43%. However, GI complications portend a significant mortality. The implications of intraoperative administration of fresh-frozen plasma and insertion of an intraaortic balloon pump deserve further investigation as they are associated with GI complications.
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