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Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
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Aortic valve bypass for aortic stenosis in a patient with paroxysmal nocturnal hemoglobinuria

Mehrdad Ghoreishi1, Maria R Baer, Ranjana Bhargava

  • 1Department of Cardiac Surgery, University of Maryland Medical Center, Baltimore, Maryland, USA.

The Annals of Thoracic Surgery
|July 9, 2010
PubMed

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired bone marrow disorder characterized by hemolytic anemia, neutropenia, thrombocytopenia, hemoglobinuria, and venous thrombosis. Cardiopulmonary bypass-induced complement activation may be associated with exacerbation of hemolysis in patients with PNH undergoing cardiac operations. We describe a 77-year-old man with PNH and critical symptomatic aortic stenosis who underwent successful aortic valve bypass operation without cardiopulmonary bypass as an alternative to conventional aortic valve replacement.

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