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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Exchange transfusion before cardiopulmonary bypass in sickle cell disease

Karl A Bocchieri1, S Jacob Scheinerman, L Michael Graver

  • 1Department of Cardiac and Thoracic Surgery, North Shore-LIJ Health System, Long Island Jewish Medical Center, New Hyde Park, New York, USA.

The Annals of Thoracic Surgery
|July 9, 2010
PubMed

Cardiac operations in patients with sickle cell disease present the surgical team with many challenges. We describe a method of complete intraoperative exchange transfusion in the operating room that reduces the hemoglobin S (Hb S) level to less than 5%, without preoperative exchange transfusions. Plasma and platelet fractions separated intraoperatively from the patient's native red cell mass were used, in addition to hemoconcentration while on cardiopulmonary bypass, to effectively reduce the red cell and clotting factor transfusion requirements after the procedure. The technique is useful in reducing transfusion requirements, avoiding cardiovascular stress associated with exchange transfusion before the operation, and can be used in urgent situations.

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