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Related Experiment Video

Updated: Jun 11, 2026

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

Postoperative mycotic endophthalmitis.

Florian Rensch¹, Frank C Schlichtenbrede, Jost B Jonas

¹Department of Ophthalmology, Medical Faculty Mannheim of Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.

Journal of Cataract and Refractive Surgery

|July 9, 2010

Summary

This summary is machine-generated.

Post-cataract surgery low-grade mycotic endophthalmitis caused by Candida species can occur months later. Early treatment with antifungal agents is crucial, though visual outcomes may be impacted by retinal and optic nerve atrophy.

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Area of Science:

Ophthalmology
Mycology
Infectious Diseases

Background:

Cataract surgery is a common procedure with a low risk of infection.
Postoperative endophthalmitis can manifest in various forms, including low-grade mycotic infections.

Observation:

A series of four patients developed low-grade mycotic endophthalmitis 3-7 months after uneventful cataract surgery.
Causative agents identified were Candida parapsilosis (3 patients) and Candida albicans (1 patient).
Treatment involved intraocular and systemic amphotericin B, with one patient undergoing pars plana vitrectomy.

Findings:

Visual acuities at 12 months post-treatment ranged from 0.2 to hand motion.
Significant visual acuity reduction was primarily attributed to retinal and optic nerve atrophy.
Mycotic etiology should be considered in delayed-onset, low-grade postoperative endophthalmitis.

Implications:

Highlights the importance of considering fungal infections in persistent or delayed postoperative endophthalmitis.
Emphasizes the need for prompt microbiological diagnosis and targeted antifungal therapy.
Suggests potential long-term visual morbidity despite treatment, necessitating ongoing patient monitoring.