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Published on: November 18, 2018
Pulmonary hypertension in heart failure
1Department of Cardiology, University of South Florida, Tampa, Florida 33618, USA. mguglin@health.usf.edu
Journal of Cardiac Failure
|July 9, 2010
Summary
Pulmonary hypertension is common in heart failure patients, impacting survival. It can improve with treatment addressing cardiac pressures and may benefit from interventions targeting vascular remodeling.
Area of Science:
- Cardiology
- Pulmonary Medicine
Background:
- Pulmonary hypertension affects 60-80% of heart failure patients.
- Associated with significant morbidity and mortality.
Purpose of the Study:
- To explore the nature and potential treatments for pulmonary hypertension in heart failure.
Main Methods:
- Correlation analysis of pulmonary artery pressure and left ventricular end-diastolic pressure.
- Assessment of reversibility with pressure normalization and interventions.
Main Results:
- Pulmonary hypertension is linked to elevated left ventricular end-diastolic pressure.
- It is prevalent in both preserved and reduced ejection fraction heart failure.
- Partially reversible with normalized filling pressures; vascular remodeling may improve with specific therapies.
Conclusions:
- Investigating idiopathic pulmonary arterial hypertension drugs for heart failure-related pulmonary hypertension is warranted.
- Left ventricular assist devices show promise for improving vascular remodeling.
- Further clinical trials are needed for heart failure patients with elevated pulmonary artery pressure.
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