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Updated: Jun 11, 2026
Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
Published on: July 1, 2013
Osseointegration of titanium implants with a roughened surface containing hydride ion in a rabbit model
Zhipeng Cheng1, Feng Zhang, Fuming He
1Department of Implantology, Stomatology Hospital, School of Medical, Zhejiang University, Hangzhou, China.
Objective:
The objective of this study was to investigate the effect of hydride ion on bone formation and bone-bonding strength at the early stage of implantation.
Study Design:
Implants and plates were treated in 2 ways: test implant (implant surface with hydride ion) and control implant (implant surface without hydride ion). Crystal structure of plate surfaces was analyzed by low angle x-ray diffractometry (XRD). Sixty implants (30 test implants and 30 control implants) were inserted into tibias of 10 rabbits. At 2 and 8 weeks postimplantation, tibias were retrieved and prepared for removal torque tests (RTQ) and histomorphometric evaluation, respectively.
Results:
TiH(2) diffractions appeared on the XRD pattern of the test surface whereas TiH(2) did not appear on the control surface. The test implants showed 51.28% and 64.63% greater RTQ values than did the control implants at 2 and 8 weeks (P = .010, .011, respectively). Histomorphometric evaluation demonstrated the test implants significantly increased bone-implant contact and peri-implant bone formation at 2 and 8 weeks.
Conclusion:
These results suggest the presence of hydride ion in the implant surface may improve bone integration with implant surfaces at the early stage of implantation.
