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Bone disease in elderly individuals with CKD

Sheru Kansal1, Linda Fried

  • 1University of Pittsburgh School of Medicine, PA 15261, USA. kansals@upmc.edu <kansals@upmc.edu>

Advances in Chronic Kidney Disease
|July 9, 2010
PubMed

Insights

Osteoporosis and chronic kidney disease (CKD) are prevalent bone diseases. In elderly patients, their interplay is complex and requires further investigation for effective management strategies.

Area of Science:

  • Nephrology
  • Endocrinology
  • Geriatrics

Background:

  • Bone disease contributes significantly to morbidity and mortality.
  • Osteoporosis and chronic kidney disease (CKD) are major causes of bone disease.
  • Management of bone disease in elderly CKD patients is complex and poorly defined.

Purpose of the Study:

  • To highlight the complexity of bone disease in elderly patients with CKD.
  • To emphasize the need for a better understanding of the interplay between aging-related bone loss and CKD-induced mineral metabolism changes.
  • To suggest that traditional bone disease management paradigms may be inadequate for this population.

Main Methods:

  • Review of current understanding of bone disease in aging and CKD.
  • Analysis of mineral metabolism changes in renal function loss.
  • Examination of the interplay between aging and CKD on bone health.

Main Results:

  • Mineral metabolism alterations in CKD exacerbate age-related bone loss.
  • Combined effects create a unique spectrum of bone disease.
  • Traditional management approaches may not be suitable for elderly CKD patients.

Conclusions:

  • Bone disease in elderly patients with CKD is a complex challenge.
  • Further research is needed to define appropriate management strategies.
  • The aging dialysis population requires focused attention on this dual pathology.

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