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Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

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Related Experiment Video

Updated: Jun 11, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Bone disease in elderly individuals with CKD.

Sheru Kansal1, Linda Fried

  • 1University of Pittsburgh School of Medicine, PA 15261, USA. kansals@upmc.edu <kansals@upmc.edu>

Advances in Chronic Kidney Disease
|July 9, 2010
PubMed
Summary

Osteoporosis and chronic kidney disease (CKD) are prevalent bone diseases. In elderly patients, their interplay is complex and requires further investigation for effective management strategies.

Area of Science:

  • Nephrology
  • Endocrinology
  • Geriatrics

Background:

  • Bone disease contributes significantly to morbidity and mortality.
  • Osteoporosis and chronic kidney disease (CKD) are major causes of bone disease.
  • Management of bone disease in elderly CKD patients is complex and poorly defined.

Purpose of the Study:

  • To highlight the complexity of bone disease in elderly patients with CKD.
  • To emphasize the need for a better understanding of the interplay between aging-related bone loss and CKD-induced mineral metabolism changes.
  • To suggest that traditional bone disease management paradigms may be inadequate for this population.

Main Methods:

  • Review of current understanding of bone disease in aging and CKD.
  • Analysis of mineral metabolism changes in renal function loss.

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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

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Last Updated: Jun 11, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

  • Examination of the interplay between aging and CKD on bone health.

    • Main Results:

    • Mineral metabolism alterations in CKD exacerbate age-related bone loss.
    • Combined effects create a unique spectrum of bone disease.
    • Traditional management approaches may not be suitable for elderly CKD patients.

    Conclusions:

    • Bone disease in elderly patients with CKD is a complex challenge.
    • Further research is needed to define appropriate management strategies.
    • The aging dialysis population requires focused attention on this dual pathology.