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Updated: Jun 11, 2026

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Published on: October 18, 2011

Cognitive function in radiologically isolated syndrome.

Christine Lebrun¹, Frederic Blanc, David Brassat

¹Department of Neurology of Nice University, France. lebrun.c@chu-nice.fr

Multiple Sclerosis (Houndmills, Basingstoke, England)

|July 9, 2010

Summary

This summary is machine-generated.

Radiologically isolated syndrome (RIS) patients exhibit cognitive deficits similar to multiple sclerosis (MS) patients, indicating potential early-stage neurological changes. Further research is needed to link these cognitive impairments with MRI markers.

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Last Updated: Jun 11, 2026

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Published on: October 18, 2011

Area of Science:

Neurology
Neuroimmunology
Cognitive Neuroscience

Background:

Radiologically isolated syndrome (RIS) presents asymptomatic T2 hypersignals on MRI, suggestive of subclinical multiple sclerosis (MS).
Previous research identified visual evoked potential and cerebrospinal fluid markers for MS conversion.
Cognitive function in RIS patients has not been previously investigated.

Purpose of the Study:

To investigate cognitive function in a cohort of 26 RIS patients.
To compare cognitive performance between RIS, MS, and healthy control groups.

Main Methods:

Prospective assessment of 26 RIS patients using the BCcogSEP cognitive test battery.
Comparison of cognitive performance with 26 MS patients and 26 age-, sex-, and education-matched healthy subjects.
Utilized tests including Paced Auditory Serial Addition Test (PASAT), phonemic fluencies, WAIS code, digit span, cross-tapping, and Go-No-Go.

Main Results:

RIS and MS groups showed significantly lower cognitive performance than healthy subjects in several tests (PASAT, phonemic fluencies, WAIS code, digit span, cross-tapping, Go-No-Go).
MS patients performed significantly worse than RIS patients on the direct digit span and cross-tapping test.
No significant differences were found for other tests, nor correlations between clinical, biological, MRI results, and cognitive dysfunction.

Conclusions:

This study supports the concept that RIS patients share cognitive features with MS patients.
Further research is required to validate these findings and explore correlations between cognitive deficits and MRI surrogate markers in RIS.