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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Issues And Trends In Healthcare Delivery System01:29

Issues And Trends In Healthcare Delivery System

The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Whole Body Regeneration01:33

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential; even...
What is Genetic Engineering?00:49

What is Genetic Engineering?

Overview

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Related Experiment Video

Updated: Jun 11, 2026

Development of New Therapeutic Applications Using Microfluidics
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Published on: October 1, 2007

Engineering new medicine: an interview with James Collins.

James Collins1

  • 1Center for BioDynamics, Boston University, MA, USA. collins@bu.edu

Disease Models & Mechanisms
|July 9, 2010
PubMed
Summary

James (Jim) Collins tackles diverse applications, from synthetic gene networks to antibiotic resistance. His engineering approach thrives on problem-solving and embracing failure for innovation.

Area of Science:

  • Biomedical Engineering
  • Synthetic Biology
  • Neuroscience

Background:

  • Investigates the interdisciplinary connections between synthetic gene networks, neural response dynamics, and the evolution of antibiotic resistance.
  • Highlights the unique problem-solving methodologies employed by engineer James (Jim) Collins.

Discussion:

  • Explores how diverse biological and engineering challenges can be unified through an applications-oriented perspective.
  • Emphasizes the role of "freedom to fail" as a catalyst for innovation in complex scientific endeavors.

Key Insights:

  • Identifies a common thread in seemingly disparate fields: the drive to solve real-world problems.
  • Showcases an unconventional engineering mindset that leverages failure as a learning opportunity.

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Using Micro-Electro-Mechanical Systems (MEMS) to Develop Diagnostic Tools

Published on: October 1, 2007

Related Experiment Videos

Last Updated: Jun 11, 2026

Development of New Therapeutic Applications Using Microfluidics
08:56

Development of New Therapeutic Applications Using Microfluidics

Published on: October 1, 2007

BioMEMS: Forging New Collaborations Between Biologists and Engineers
07:26

BioMEMS: Forging New Collaborations Between Biologists and Engineers

Published on: November 1, 2007

Using Micro-Electro-Mechanical Systems (MEMS) to Develop Diagnostic Tools
16:05

Using Micro-Electro-Mechanical Systems (MEMS) to Develop Diagnostic Tools

Published on: October 1, 2007

Outlook:

  • Suggests potential for cross-disciplinary breakthroughs by applying similar innovative strategies to new challenges.
  • Positions "freedom to fail" as a critical component for advancing scientific and engineering frontiers.