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Related Experiment Video

Updated: Jun 11, 2026

A Cost-Effective and Minimally Invasive Protocol for Chronic Multi-Site Electroencephalography Recording in Freely Moving Mice
07:47

A Cost-Effective and Minimally Invasive Protocol for Chronic Multi-Site Electroencephalography Recording in Freely Moving Mice

Published on: October 10, 2025

High resolution electroencephalography in freely moving mice.

Jee Hyun Choi1, Klaus Peter Koch, Wigand Poppendieck

  • 1Center for Neural Science, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Republic of Korea.

Journal of Neurophysiology
|July 9, 2010
PubMed
Summary

We developed a high-density microelectrode array for high-resolution electroencephalography (EEG) in mice. This technology overcomes spatial limitations, enabling detailed brain state monitoring and the study of neural mechanisms.

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Electrophysiology

Background:

  • Electroencephalography (EEG) is crucial for monitoring brain states.
  • Mouse models are vital for studying molecular and cellular mechanisms of EEG rhythms.
  • The small mouse brain limits spatial resolution in conventional EEG.

Purpose of the Study:

  • To overcome spatial limitations of mouse EEG.
  • To develop a high-density microelectrode array for high-resolution EEG (HR-EEG) in mice.
  • To enable detailed mapping and dynamical analysis of mouse brain activity.

Main Methods:

  • Fabrication of a 32-electrode polyimide-based microelectrode array (PBM array) using nanofabrication.
  • Application of the PBM array on the mouse skull for noise-insensitive signal acquisition.

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High-density EEG Recordings of the Freely Moving Mice using Polyimide-based Microelectrode
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High-density EEG Recordings of the Freely Moving Mice using Polyimide-based Microelectrode

Published on: January 11, 2011

High-density Electroencephalographic Acquisition in a Rodent Model Using Low-cost and Open-source Resources
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High-density Electroencephalographic Acquisition in a Rodent Model Using Low-cost and Open-source Resources

Published on: November 26, 2016

Related Experiment Videos

Last Updated: Jun 11, 2026

A Cost-Effective and Minimally Invasive Protocol for Chronic Multi-Site Electroencephalography Recording in Freely Moving Mice
07:47

A Cost-Effective and Minimally Invasive Protocol for Chronic Multi-Site Electroencephalography Recording in Freely Moving Mice

Published on: October 10, 2025

High-density EEG Recordings of the Freely Moving Mice using Polyimide-based Microelectrode
06:59

High-density EEG Recordings of the Freely Moving Mice using Polyimide-based Microelectrode

Published on: January 11, 2011

High-density Electroencephalographic Acquisition in a Rodent Model Using Low-cost and Open-source Resources
12:39

High-density Electroencephalographic Acquisition in a Rodent Model Using Low-cost and Open-source Resources

Published on: November 26, 2016

  • Development of mapping and dynamical analysis tools for spatially resolved EEG data.

    • Main Results:

    • The PBM array provides high-resolution EEG (HR-EEG) with global and focused mapping capabilities.
    • Demonstrated utility in localizing seizure onset in an absence seizure model.
    • Showcased phase dynamics of abnormal theta rhythm in transgenic mice.

    Conclusions:

    • The developed PBM array significantly enhances spatial information in mouse EEG.
    • This technology facilitates the study of molecular and cellular mechanisms underlying EEG rhythms.
    • Enables dynamic tracking of EEG maps in freely moving genetically modified mice for advanced neuroscience research.