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Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
Published on: March 8, 2015
Deep brain stimulation for hyperkinetics disorders: dystonia, tardive dyskinesia, and tics
Marie-Laure Welter1, David Grabli, Marie Vidailhet
1AP-HP, Fédération des Maladies du Système Nerveux, Université Pierre et Marie Curie-Paris, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
Current Opinion in Neurology
|July 9, 2010
Summary
Deep brain stimulation (DBS) effectively treats hyperkinetic movement disorders like dystonia and Tourette
Area of Science:
- Neurology
- Neurosurgery
- Movement Disorders
Background:
- Hyperkinetic movement disorders encompass dystonia, tardive dyskinesia, and Tourette's syndrome.
- Deep brain stimulation (DBS) is an emerging therapeutic option for these conditions.
Purpose of the Study:
- To review recent advancements in DBS for hyperkinetic movement disorders.
- To synthesize findings on DBS efficacy and target selection.
Main Methods:
- Review of recent literature (last 18 months) on DBS for dystonia, tardive dyskinesia, and Tourette's syndrome.
- Analysis of controlled studies and case reports.
Main Results:
- High-frequency globus pallidus internus (GPi) stimulation is effective for primary and tardive dystonia, with stable long-term effects.
- DBS of the thalamus (centre-median/parafascicular nucleus) and GPi shows efficacy for Tourette's syndrome.
- Data for secondary dystonia and alternative targets like the nucleus accumbens are less conclusive.
Conclusions:
- Bilateral GPi stimulation is a well-tolerated, long-term treatment for hyperkinetic disorders.
- Further controlled studies are needed to optimize DBS targets for specific patient populations and secondary dystonia.
