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Related Experiment Videos

Dose distribution following selective internal radiation therapy.

R A Fox1, P F Klemp, G Egan

  • 1Department of Medical Physics, Royal Perth Hospital, Australia.

International Journal of Radiation Oncology, Biology, Physics
|July 1, 1991
PubMed
Summary

Selective Internal Radiation Therapy (SIRT) using 90Y microspheres delivers targeted radiation to liver tumors. While effective, dose distribution in normal liver tissue is heterogeneous, impacting treatment planning.

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Area of Science:

  • Oncology
  • Radiotherapy
  • Nuclear Medicine

Background:

  • Selective Internal Radiation Therapy (SIRT) involves intrahepatic arterial injection of 90Y-labeled microspheres.
  • This technique delivers targeted internal radiation therapy to liver tumors by lodging microspheres in the tumor's vascular supply.
  • Current methods involve dose assessment using beta probes on normal liver tissue after successive administrations.

Purpose of the Study:

  • To analyze the dose distribution of 90Y microspheres within normal liver tissue.
  • To investigate the heterogeneity of radiation dose delivered by microspheres.
  • To compare predicted homogeneous dose with actual heterogeneous distribution.

Main Methods:

  • Detailed analysis of microsphere distribution in a cubic centimeter of normal liver.

Related Experiment Videos

  • Calculation of radiation dose to a 3-dimensional fine grid.
  • Assessment of dose heterogeneity based on microsphere size and distribution.

    • Main Results:

    • Selective Internal Radiation Therapy (SIRT) with 90Y microspheres can deliver high doses (e.g., 75 Gy) without apparent normal tissue damage, unlike external beam radiotherapy.
    • Analysis revealed a highly heterogeneous dose pattern due to the finite size and distribution of microspheres.
    • A significant portion (one-third) of normal liver tissue received substantially less radiation than predicted assuming homogeneous distribution.

    Conclusions:

    • The dose distribution from 90Y microspheres in SIRT is significantly heterogeneous.
    • This heterogeneity means that a substantial volume of normal liver tissue may receive a lower dose than anticipated.
    • Accurate dosimetry requires accounting for microsphere distribution to optimize treatment and avoid underdosing normal tissue.