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Related Experiment Video

Updated: Jun 11, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Cranial reconstruction using bioabsorbable calcified triglyceride bone cement.

Giuseppe di Nuzzo¹, Marianna Luongo, Ciro Parlato

¹Department of Neurosurgery, Seconda Università di Napoli, Naples, Italy. giuseppe.dinuzzo@unina2.it

The Journal of Craniofacial Surgery

|July 9, 2010

Summary

KRYPTONITE Bone Cement offers a safe and effective solution for cranial reconstruction, demonstrating excellent bioabsorbability and osteoconductivity. This study highlights its successful application in six patients, achieving good aesthetic results without complications.

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Area of Science:

Neurosurgery
Biomaterials Science
Orthopedic Surgery

Background:

Cranial reconstruction presents challenges in achieving optimal aesthetic and functional outcomes.
Bioabsorbable materials offer potential advantages over traditional fixation methods.

Purpose of the Study:

To evaluate the efficacy and safety of KRYPTONITE Bone Cement for cranial reconstruction in patients undergoing supratentorial tumor removal.
To assess the material's properties, including handling, bioabsorbability, and osteoconductivity.

Main Methods:

Six patients with supratentorial tumors had cranial defects reconstructed using KRYPTONITE Bone Cement.
Craniocerebral imaging (MRI and CT) was performed preoperatively and at 7 days and 12 months post-surgery.
One patient received reconstruction without additional fixation systems.

Main Results:

KRYPTONITE Bone Cement exhibited favorable handling characteristics: injectable for 8 minutes, becoming adhesive thereafter.
Postoperative CT scans at 7 days showed excellent bone alignment and defect filling with no complications.
12-month follow-up CT scans confirmed the cement's bioabsorbability and osteoconductivity, with good aesthetic results.

Conclusions:

KRYPTONITE Bone Cement is a versatile, easy-to-use material for cranial reconstruction with desirable properties like bioabsorbability and osteoconductivity.
Its application without fixation systems in one case represents a novel approach, achieving satisfactory outcomes.
The cement is nonthermal conducting, radiopaque, nonmagnetic, and lightweight, simplifying surgical procedures.