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Mucoepidermoid carcinoma with spindle cell change: a low-grade lesion potentially mistaken for sarcomatoid
Fumio Ide1, Kenji Mishima, Ichiro Saito
1Department of Pathology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, Japan. ide-f@tsurumi-u.ac.jp
Abstract:
An unusual case of mucoepidermoid carcinoma (MEC) of intraoral minor salivary gland origin with spindled morphology was presented. A fascicular stream of bland spindle cells from typical MEC areas amounted to more than 70% of the tumor. Spindle population had features consistent with immunohistochemical and ultrastructural profiles of intermediate cells and lacked overexpression of p53 and cyclin D1. There was no difference in the Ki-67 index between two distinct components. Awareness of extensive spindle cell change replacing a significant portion of low-grade MEC is crucial to avoid an erroneous interpretation of dedifferentiated sarcomatoid transformation.
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