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Simian adenoviral pneumonia.

J T Boyce, W E Giddens, M Valerio

    The American Journal of Pathology
    |May 1, 1978
    PubMed
    Summary

    Fatal adenoviral pneumonia caused by simian adenovirus 11 occurred in young simian primates. This study highlights its potential as a model for human adenoviral pneumonia research.

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    Area of Science:

    • Veterinary Pathology
    • Virology
    • Primate Medicine

    Background:

    • Adenoviral pneumonia is a significant cause of mortality in young simian primates.
    • Previous studies have documented adenoviral infections in primates, but a comprehensive analysis of fatal pneumonia is limited.

    Purpose of the Study:

    • To characterize the clinical, pathological, and etiological features of fatal adenoviral pneumonia in simian primates.
    • To evaluate the potential of simian adenoviral pneumonia as a model for human adenoviral pneumonia.

    Main Methods:

    • Retrospective analysis of 26 cases of fatal pneumonia in six simian primate species over six years.
    • Necropsy, histopathology, and ultrastructural examination of affected tissues.
    • Isolation of simian adenovirus 11 and serological testing.

    Main Results:

    • Pneumonia was the primary cause of death in 22 of 26 cases, predominantly affecting infants (11-38 days old).
    • Histopathology revealed necrotizing alveolitis and bronchiolitis with characteristic basophilic intranuclear inclusions.
    • Simian adenovirus 11 was identified as the causative agent in an outbreak, with evidence of viral particles on ultrastructural examination.

    Conclusions:

    • Simian adenoviral pneumonia is a critical spontaneous disease in laboratory primates.
    • The pathological findings and viral etiology make it a relevant animal model for studying human adenoviral pneumonia.

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