Activity of extracts and procesterol from Calotropis gigantea against Entamoeba histolytica
Shailendra Singh1, Neelam Bharti, Manoj Chugh
1Department of Natural Products, National Institute of Pharmaceutical Education & Research (NIPER), S-G Highway, Thaltej, Ahmedabad-380054, India. shailench@yahoo.co.in
Natural Product Communications
|July 10, 2010
Abstract:
Extracts from the root bark of Calotropis gigantea were subjected to bioactivity-guided fractionation using growth inhibitory effects against Entamoeba histolytica. The n-hexane soluble portion of the chloroform extract showed in vitro antiamoebic activity against the HK-9 strain of Entamoeba histolytica. Chromatographic separation of the chloroform extract afforded the known compound, procesterol, which showed activity against E. histolytica.


