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Related Experiment Video

Updated: Jun 11, 2026

Enhanced Photoluminescence of Curcuma longa Extracts via Chitosan-Mediated Energy Transfer for Textile Authentication Applications

Enhanced Photoluminescence of Curcuma longa Extracts via Chitosan-Mediated Energy Transfer for Textile Authentication Applications

Published on: December 22, 2023

Colon targeted curcumin delivery using guar gum.

Edwin J Elias¹, Singhal Anil, Showkat Ahmad

¹TIFAC-CORE in Green Pharmacy, B. R. Nahata College of Pharmacy, Mhow-Neemuch Road, Mandsaur - 458001, Madhya Pradesh, India. ejeru@rediffmail.com

Natural Product Communications

|July 10, 2010

Summary

This study developed guar gum matrix tablets for curcumin colon delivery. The 40% guar gum formulation demonstrated optimal curcumin release for effective colon cancer treatment.

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Last Updated: Jun 11, 2026

Enhanced Photoluminescence of Curcuma longa Extracts via Chitosan-Mediated Energy Transfer for Textile Authentication Applications

Enhanced Photoluminescence of Curcuma longa Extracts via Chitosan-Mediated Energy Transfer for Textile Authentication Applications

Published on: December 22, 2023

Area of Science:

Pharmacology
Drug Delivery Systems
Gastroenterology

Background:

Curcumin shows promise for colon cancer treatment but suffers from poor gastrointestinal absorption.
The colon presents an ideal environment for drug delivery due to its pH, enzymatic activity, transit time, and absorption enhancer responsiveness.

Purpose of the Study:

To develop a guar gum-based matrix tablet for curcumin delivery to the colon.
To evaluate the in vitro mouth-to-colon release profile and mechanical properties of curcumin tablets.

Main Methods:

Three curcumin formulations with varying guar gum concentrations (40% and 50%) were prepared using wet granulation.
Tablets were evaluated for hardness, friability, drug content uniformity, and in vitro drug release in simulated gastrointestinal fluids.
Guar gum's susceptibility to colonic bacteria was assessed using rat cecal contents.

Main Results:

The 40% guar gum formulation (F-1) exhibited superior curcumin release (91.1% at 24 hours) in the presence of rat cecal contents compared to the 50% formulation (F-2, 82.1%).
Formulation F-1 demonstrated promising in vitro mouth-to-colon release characteristics.

Conclusions:

Guar gum is a suitable polymer for developing colon-targeted curcumin delivery systems.
This approach holds potential for enhancing curcumin's efficacy in treating colon cancer.