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Related Concept Videos

Colloidal precipitates01:09

Colloidal precipitates

The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...

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Dextran coatings for aggregation control of layer-by-layer assembled polyelectrolyte microcapsules.

Denys Usov1, Gleb B Sukhorukov

  • 1School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, United Kingdom. d.usov@qmul.ac.uk

Langmuir : the ACS Journal of Surfaces and Colloids
|July 10, 2010
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Summary

Dextran and dextran polyaldehyde coatings stabilize polyelectrolyte microcapsules against aggregation in ionic solutions. These coatings enhance capsule wall strength, enabling pH-triggered release and improved colloid stability for various applications.

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Colloid Science

Background:

  • Layer-by-layer (LbL) assembled polyelectrolyte microcapsules often lack stability in aqueous ionic solutions.
  • Modification of microcapsule surfaces is crucial for enhancing their stability and functionality.
  • Dextran and its derivatives offer potential for surface modification due to their biocompatibility and reactive groups.

Purpose of the Study:

  • To develop dextran and dextran polyaldehyde (DPA) coatings for stabilizing LbL polyelectrolyte microcapsules.
  • To investigate the effect of different chemical bond strengths on microcapsule stability and wall integrity.
  • To explore the potential applications of these coated microcapsules in colloid stabilization and controlled release.

Main Methods:

  • Fabrication of polyelectrolyte microcapsules using three bilayers of poly(4-styrenesulfonate) (PSS) and poly(allylamine) (PAH).
  • Coating of microcapsules with dextran and DPA via hydrogen bonds, hydrolyzable covalent bonds (aldehyde-amine), and non-hydrolyzable covalent bonds (secondary amines).
  • Assessment of microcapsule stability in high ionic strength solutions (0.75 M) and alkaline conditions (0.1 M NaOH), including swelling and disintegration tests.
  • Chemical modification of coatings via reduction with sodium borohydride (NaBH(4)) to convert hydrolyzable to non-hydrolyzable bonds.

Main Results:

  • Dextran and DPA coatings significantly improved microcapsule stability against aggregation in 0.75 M ionic solutions.
  • Coatings formed via hydrolyzable and non-hydrolyzable covalent bonds (DPA) strengthened microcapsule walls, preserving them from disintegration in 0.1 M NaOH.
  • Higher aldehyde content in DPA and conversion to non-hydrolyzable bonds increased capsule survival fraction and reduced alkaline swelling.
  • Hydrogen-bonded dextran coatings and bare microcapsules dissolved completely under alkaline conditions.

Conclusions:

  • Dextran and DPA coatings provide effective colloid stabilization for polyelectrolyte microcapsules in aqueous media.
  • The strength of chemical linkages in the coatings critically influences microcapsule wall integrity and stability.
  • These modified microcapsules are suitable for post-preparation encapsulation of pH-insensitive macromolecules and for pH-triggered release applications.