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DP(2) receptor antagonists in development
1Norman Consulting, Burnham, Bucks, UK. peter.norman2@btinternet.com
Expert Opinion on Investigational Drugs
|July 10, 2010
Summary
Selective DP(2) antagonists show promise for treating asthma by blocking prostaglandin D(2) (PGD(2)) effects. Further clinical data will clarify their therapeutic potential for asthma and COPD.
Area of Science:
- Pharmacology
- Immunology
- Respiratory Medicine
Background:
- Allergen challenge in asthma increases prostaglandin D(2) (PGD(2)), causing airway contraction and inflammation.
- PGD(2) acts on the DP(2) receptor, with limited inhibition by other antagonists, necessitating selective DP(2) antagonists.
- Initial clinical data for DP(2) antagonists are promising, driving interest in their development.
Purpose of the Study:
- To review the development of selective DP(2) antagonists for asthma treatment.
- To identify companies actively developing these agents.
Main Methods:
- Consideration of 10 DP(2) antagonists in clinical development.
- Review of preclinical efforts and comparison with advanced agents.
Main Results:
- Comprehensive overview of the current state of DP(2) antagonist development.
- Identification of key companies in this therapeutic area.
Conclusions:
- Significant progress in developing selective DP(2) antagonists for asthma.
- Potential new treatment option for asthma, with possible applications in COPD pending further clinical results.
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