Burden of childhood-onset arthritis

Lakshmi N Moorthy1, Margaret Ge Peterson, Afton L Hassett

  • 1Robert Wood Johnson Medical School-UMDNJ, Dept, of Pediatrics Room 1361, 89 French Street, New Brunswick, NJ, USA. moorthln@umdnj.edu.

Insights

Juvenile arthritis (JA) causes chronic inflammation and disability in children, impacting their quality of life and leading to long-term health issues. Addressing JA requires tailored interventions for better patient outcomes and reduced societal costs.

Area of Science:

  • Pediatric Rheumatology
  • Public Health
  • Disability Studies

Background:

  • Juvenile arthritis (JA) encompasses chronic inflammatory conditions leading to childhood erosive arthritis and potential disability.
  • JA significantly impairs children's physical function through pain, stiffness, and swelling, with potential complications like blindness from uveitis.

Purpose of the Study:

  • To review the multifaceted burden of juvenile arthritis on patients, families, and society.
  • To highlight key areas of impact including disability, visual outcomes, medical complications, and quality of life.

Main Methods:

  • Literature review of existing studies on juvenile arthritis.
  • Analysis of patient disability, visual outcomes, medical complications, physical activity, HRQOL, emotional impact, pain, healthcare utilization, economic impact, caregiver burden, transition, education, and sexuality.

Main Results:

  • JA imposes a substantial burden on patients' and families' lives, affecting health-related quality of life, physical function, and visual outcomes.
  • The condition impacts school and home functioning, necessitating interventions for improved transition to adult care, vocational outcomes, and cost reduction.

Conclusions:

  • Effective, tailored interventions are crucial to mitigate the impact of juvenile arthritis.
  • Addressing JA requires a comprehensive approach to improve patient functioning, support caregivers, and reduce societal healthcare costs.

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...