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Updated: Jun 11, 2026

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
Life-threatening haemorrhage secondary to nicorandil-induced severe peri-anal ulceration
F Mosley1, N Bhasin, J B Davies
1Department of General Surgery, Bradford Royal Infirmary, Bradford, UK. Frances_Mosley@yahoo.co.uk
Abstract:
Nicorandil-induced ulceration is rare but has been reported at multiple sites throughout the gastrointestinal tract. We report a life-threatening complication of such ulceration - catastrophic per-rectal haemorrhage requiring emergency surgery with no prior symptoms. Whilst nicorandil should be considered in cases of chronic peri-anal and peristomal ulceration which fail to respond to conventional treatments, this case highlights its importance in the setting of acute surgical presentations.
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